Bases Moleculares da Regulação Gênica

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Regulação pós-transcricional - decaimento RNA

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Profa Tie Koide

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Artigo de revisão  19/04:

All things must pass: contrasts and commonalities in eukaryotic and bacterial mRNA decay. Belasco JG. Nat Rev Mol Cell Biol. 2010 Jul;11(7):467-78


Artigo contemporâneo - 26/04: Marjorie Pontelli

Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells. Rabani M, Levin JZ, Fan L, Adiconis X, Raychowdhury R, Garber M, Gnirke A, Nusbaum C, Hacohen N, Friedman N, Amit I, Regev A. Nat Biotechnol. 2011 May;29(5):436-42.


Artigo contemporâneo- 26/04: Felipe Freitas

Single-molecule mRNA decay measurements reveal promoter- regulated mRNA stability in yeast. Trcek T, Larson DR, Moldón A, Query CC, Singer RH. Cell. 2011 Dec 23;147(7):1484-97.

 

SUGESTÕES DE LEITURA

The highways and byways of mRNA decay. Garneau NL, Wilusz J, Wilusz CJ. Nat Rev Mol Cell Biol. 2007 Feb;8(2):113-26.

Mechanisms and Consequences of Alternative Polyadenylation Di Giammartino DC, Nishida K, Manley JL. Mol Cell. 2011 Sep 16;43(6):853-66

Ribonuclease E is a 5'-end-dependent endonuclease. Nature. 1998 Oct 15;395(6703):720-3. Mackie GA.

The many pathways of RNA degradation. Houseley J, Tollervey D. Cell 2009 136, 763-776.

Last Updated on Monday, 21 May 2012 16:20