Bases Moleculares da Regulação Gênica

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Estocasticidade na expressão gênica

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Profa. Tie Koide

Aula

Artigos de revisão- 14/06:

Functional roles for noise in genetic circuits. Eldar A, Elowitz MB. Nature. 2010 Sep 9;467(7312)


 

Artigos Seminais - (a definir) 21/06: Felipe ten Caten

Stochastic gene expression in a single cell. Elowitz MB, Levine AJ, Siggia ED, Swain PS. Science. 2002 Aug 16;297(5584):1183

 

Artigos contemporâneos (a definir) - 21/06: Livia Zaramela

Real-time observation of transcription initiation and elongation on an endogenous yeast gene. Larson DR, Zenklusen D, Wu B, Chao JA, Singer RH. Science. 2011 Apr 22;332(6028):475-8.


Sugestões de leitura:

A single molecule view of gene expression. Larson DR, Singer RH, Zenklusen D. Trends Cell Biol. 2009 Nov;19(11):630

Nature, nurture, or chance: stochastic gene expression and its consequences. Raj A, van Oudenaarden A. Cell. 2008 Oct 17;135(2):216-26.

Stochastic mechanisms in gene expression. McAdams HH, Arkin A. Proc Natl Acad Sci U S A. 1997

General properties of transcriptional time series in Escherichia coli. So LH, Ghosh A, Zong C, Sepúlveda LA, Segev R, Golding I. Nat Genet. 2011 Jun;43(6):554-60

Dynamic analysis of stochastic transcription cycles. Harper CV, Finkenstädt B, Woodcock DJ, Friedrichsen S, Semprini S, Ashall L, Spiller DG, Mullins JJ, Rand DA, Davis JR, White MR. PLoS Biol. 2011 Apr;9(4):e1000607


Last Updated on Thursday, 21 June 2012 11:41